Seminar Series by Prof. Kannan Krishnan – 1

Department of Materials Engineering
Indian Institute of Science

is pleased to invite you to the seminar on

From materials to medicine: a sp↑n through recent developments in imaging, therapy and diagnostics
by
Prof. Kannan M. Krishnan
Brahm Prakash Visiting Chair
Department of Materials Engineering
Indian Institute of Science, Bangalore
and
Department of Materials Sciences & Engineering, and Physics
University of Washington
Seattle, USA

at 3:30 p.m.
on 12.1.2016 (Tuesday)
in the Lecture Theatre, Department of Materials Engineering.

Abstract

The Néel relaxation of magnetic nanoparticles (MNP), subject to alternating magnetic fields in solution, depends exponentially on the size of their magnetic core, whilst the complementary Brownian relaxation mechanism depends critically on their hydrodynamic volume [1,2]. Recent developments in the synthesis [3] and applications [4] of highly monodisperse and phase-pure magnetite nanoparticles, with negligible toxicity [5] and favorable biodistribution [6], allows for reproducible control of the former, even in “harsh” biological environments, enabling novel imaging [7,8,9], spectroscopic [10] and therapeutic1112 modalities, under ac excitations. With appropriate functionalization of the monodisperse cores, and utilizing the magnetic relaxation, it also allows for the development of sensitive, relaxation based assays13 for the detection of biomolecules associated with various diseases.

In this multidisciplinary talk, beginning with the physics of magnetic relaxation under ac excitation, I will describe the chemical synthesis, phase optimization, surface functionalization, and development of optimized nanoparticle tracers with magnetic properties tailored for the unique physics of Magnetic Particle Imaging –– an emerging tracer-based whole body imaging technique with no ionizing radiation, and present recent results in phantom and in vivo imaging of animal models for cardiovascular disease and molecular imaging of cancer. I will also present details of newly designed assays, using magnetic particle spectroscopy, for the detection of proteases that are closely linked to malignant phenotypes of different solid tumors and conclude with an outlook of opportunities that abound for continued research in this exciting field [14].

1. Kannan M. Krishnan, IEEE Trans. Mag. 46, 2523-2558 (2010)

2. C. Kuhlmann, A. P. Khandhar, R. M. Ferguson, S. Kemp, T. Wawrzik, M. Schilling, Kannan M. Krishnan and F. Ludwig, IEEE Trans. Mag. 51, 6500504 (2015)

3. R. Hufschmid, H. Arami, R. M. Ferguson, M. Gonzales, E. Teeman, L. Brush, N. Browning and Kannan M. Krishnan, Nanoscale, 7, 11142 (2015)

4. Y. Bao, T. Wen, A.C. Samia, A.P. Khandhar, and Kannan M. Krishnan, Jour Mater. Sci., 51, 513-553 (2016)

5. H. Arami, A. Khandhar, D. Liggitt and Kannan M. Krishnan, Chem. Soc. Rev. 44, 8576 (2015)

6. H. Arami, A. P. Khandhar, A. Tomitaka and Kannan M. Krishnan, Biomaterials 52, 251 (2015)

7. B. Gleich & J. Weizenecker, Nature 435, 1214 (2005).

8. R.M. Ferguson, A.P. Khandhar, H. Arami, E.U. Saritas, L.R. Croft, P.W. Goodwill, A. Halkola, J. Rahmer, J. Borgert, S.M. Conolly and Kannan M. Krishnan, IEEE Trans. Med. Imag. 34, 1077 (2015)

9. A. Tomitaka, S. Gandhi, H. Arami and Kannan M. Krishnan, Nanoscale 7, 16890-16898 (2015).

10. S. A. Shah, D.B. Reeves, R.M. Ferguson, J.B. Weaver, and Kannan M. Krishnan, Phys. Rev. B92, 094438 (2015)

11. A. Khandhar, R. Matthew Ferguson, Julian A. Simon and Kannan M. Krishnan, Jour. Biomedical Materials Research, Part A, 100A, 728-737 (2012)

12. S. Kalale, R. Narain and Kannan M. Krishnan, Jour. Mag. Mag. Mat. 321, 1377-1380 (2009)

13. S. Gandhi, H. Arami, Kannan M. Krishnan, Proc. Nat. Acad. Sci., (submitted)

14. This work was supported by US-NIH Grants 1RO1EB013689-01/NIBIB, 1R41EB013520-01, and 2R42EB013520-02A1.